Article
Evolutionary switches between two serine codon sets are driven by selection.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 2016
Rogozin Igor B, Belinky Frida, Pavlenko Vladimir, Shabalina Svetlana A, Kristensen David M, Koonin Eugene V
Abstract excerpt
Serine is the only amino acid that is encoded by two disjoint codon sets so that a tandem substitution of two nucleotides is required to switch between the two sets. Previously published evidence suggests that, for the most evolutionarily conserved serines, the codon set switch occurs by simultaneous substitution of two nucleotides. Here we report a genome-wide reconstruction of the evolution of serine codons in...
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