Article
Phase-dependent nucleotide substitution in protein-coding sequences.
Biochemical and biophysical research communications - 13 Apr 2007
Wang Guang-Zhong, Chen Ling-Ling, Zhang Hong-Yu
Abstract excerpt
It is well known that due to the degeneracy of genetic code, most of the silent substitutions appear in the third codon position, so the mutation frequency of the third codon position is much higher than that of the first two positions. However, it remains unknown whether the directionality of point mutation in three codon positions is similar or not. In this paper, through analyzing 15 sets of orthologous genes,...
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