Article
The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies.
Neuroreport - 7 Feb 2000
Xu W, Liu L, Emson P, Harrington C R, McKeith I G, Perry R H, Morris C M, Charles I G
Abstract excerpt
We report the analysis of the allele distribution of a (CCTTT)n pentanucleotide repeat within the promoter region of the NOS2A gene in DNA samples from patients with autopsy confirmed Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) type. A significant difference was observed in the allelic distribution between the control group and the DLB group (chi2 = 15.175, df = 5; p<0.01), with an increased...
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