Article
(CCTTT)n polymorphism of NOS2A in nasal polyposis and asthma: a case-control study.
Journal of investigational allergology & clinical immunology - 1 Jan 2008
Pascual M, Sanz C, Isidoro-García M, Dávila I, Moreno E, Laffond E, Lorente F
Abstract excerpt
BACKGROUND: Nitric Oxide (NO) has been proposed as an important signaling molecule. NO produced by the inducible NO synthase enzyme NOS2A is generated at high levels in certain types of inflammation. A pentanucleotide polypyrimidine microsatellite CCTTT has been identified in the promoter region of the NOS2A gene. OBJECTIVE: The aim of this study was to analyze the (CCTTT)n polymorphism in patients with asthma...
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