Article
A neuronal NO synthase (NOS1) gene polymorphism is associated with asthma.
Biochemical and biophysical research communications - 7 Jun 2000
Grasemann H, Yandava C N, Storm van's Gravesande K, Deykin A, Pillari A, Ma J, Sonna L A, Lilly C, Stampfer M J, Israel E, Silverman E K, Drazen J M
Abstract excerpt
Recent family-based studies have revealed evidence for linkage of chromosomal region 12q to both asthma and high total serum immunoglobulin E (IgE) levels. Among the candidate genes in this region for asthma is neuronal nitric oxide synthase (NOS1). We sought a genetic association between a polymorphism in the NOS1 gene and the diagnosis of asthma, using a case-control design. Frequencies for allele 17 and 18 of...
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