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Article

Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease.

BMC pulmonary medicine - 6 Nov 2013

Aminuddin Farzian, Hackett Tillie-Louise, Stefanowicz Dorota, Saferali Aabida, Paré Peter D, Gulsvik Amund, Bakke Per, Cho Michael H, Litonjua Augusto, Lomas David A, Anderson Wayne H, Beaty Terri H, Silverman Edwin K, Sandford Andrew J

Abstract excerpt

BACKGROUND: Due to the pleiotropic effects of nitric oxide (NO) within the lungs, it is likely that NO is a significant factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of this study was to test for association between single nucleotide polymorphisms (SNPs) in three NO synthase (NOS) genes and lung function, as well as to examine gene expression and protein levels in relation to...

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Identifiers

PMID: 24192154
DOI: 10.1186/1471-2466-13-64
PMCID: PMC3827989

Genes

NOS3
NOS1
NOS2

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