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Article

Associations between nitric oxide synthase genes and exhaled NO-related phenotypes according to asthma status.

PloS one - 1 Jan 2012

Bouzigon Emmanuelle, Monier Florent, Boussaha Mekki, Le Moual Nicole, Huyvaert Hélène, Matran Régis, Letort Sébastien, Bousquet Jean, Pin Isabelle, Lathrop Mark, Kauffmann Francine, Demenais Florence, Nadif Rachel

Abstract excerpt

BACKGROUND: The nitric oxide (NO) pathway is involved in asthma, and eosinophils participate in the regulation of the NO pool in pulmonary tissues. We investigated associations between single nucleotide polymorphisms (SNPs) of NO synthase genes (NOS) and biological NO-related phenotypes measured in two compartments (exhaled breath condensate and plasma) and blood eosinophil counts. METHODOLOGY: SNPs (N = 121)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22590587
DOI: 10.1371/journal.pone.0036672
PMCID: PMC3348876

Genes

NOS3
NOS2
NOS1

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