Article
The Arg353Gln polymorphism reduces the level of coagulation factor VII. In vivo and in vitro studies.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 1997
Hunault M, Arbini A A, Lopaciuk S, Carew J A, Bauer K A
Abstract excerpt
Factor VII levels are regulated by environmental and genetic factors. Two polymorphisms, a G-to-A transversion at nucleotide 10,976 resulting in Arg353Gln and a decanucleotide insert at position -323 in the 5'-flanking region of the factor VII gene, have been associated with a 20% to 25% reduction in plasma factor VII levels. However Arg353Gln almost always segregates on alleles containing the insert in UK and...
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