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Article

Unusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease 1.

Journal of molecular biology - 23 May 2008

Mantha Anil K, Oezguen Numan, Bhakat Kishor K, Izumi Tadahide, Braun Werner, Mitra Sankar

Abstract excerpt

The mammalian AP-endonuclease (APE1) repairs apurinic/apyrimidinic (AP) sites and strand breaks with 3' blocks in the genome that are formed both endogenously and as intermediates during base excision repair. APE1 has an unrelated activity as a redox activator (and named Ref-1) for several trans-...

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Source

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Identifiers

PMID: 18436236
DOI: 10.1016/j.jmb.2008.03.052
PMCID: PMC2708089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18436236-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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