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Article

Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice.

The European journal of neuroscience - 1 Nov 2007

Kessler Melanie S, Murgatroyd Chris, Bunck Mirjam, Czibere Ludwig, Frank Elisabeth, Jacob Wolfgang, Horvath Charlotte, Muigg Patrik, Holsboer Florian, Singewald Nicolas, Spengler Dietmar, Landgraf Rainer

Abstract excerpt

Following secretion from the posterior pituitary, the neuropeptide vasopressin (AVP) stimulates the kidney to retain water, and when released centrally it can contribute to anxiety- and depression-like behaviours. We hypothesized that CD1 mice bred for low trait anxiety (LAB) suffer from a deficit in AVP. Both osmotically stimulated peripheral secretion and intra-paraventricular nucleus (PVN) release of AVP were...

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Identifiers

PMID: 18001282
DOI: 10.1111/j.1460-9568.2007.05917.x

Genes

AVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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