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Article

Progressive polyuria without vasopressin neuron loss in a mouse model for familial neurohypophysial diabetes insipidus.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 May 2009

Hayashi Masayuki, Arima Hiroshi, Ozaki Noriyuki, Morishita Yoshiaki, Hiroi Maiko, Ozaki Nobuaki, Nagasaki Hiroshi, Kinoshita Noriaki, Ueda Masatsugu, Shiota Akira, Oiso Yutaka

Abstract excerpt

Familial neurohypophysial diabetes insipidus (FNDI), an autosomal dominant disorder, is mostly caused by mutations in the gene of neurophysin II (NPII), the carrier protein of arginine vasopressin (AVP). Previous studies suggest that loss of AVP neurons might be the cause of polyuria in FNDI. Here we analyzed knockin mice expressing mutant NPII that causes FNDI in humans. The heterozygous mice manifested...

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PMID: 19297548
DOI: 10.1152/ajpregu.00034.2009

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AVP
SON

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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