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Article

Abnormal water metabolism in mice lacking the type 1A receptor for ANG II.

American journal of physiology. Renal physiology - 1 Jan 2000

Oliverio M I, Delnomdedieu M, Best C F, Li P, Morris M, Callahan M F, Johnson G A, Smithies O, Coffman T M

Abstract excerpt

Mice lacking AT(1A) receptors for ANG II have a defect in urinary concentration manifested by an inability to increase urinary osmolality to levels seen in controls after thirsting. This defect results in extreme serum hypertonicity during water deprivation. In the basal state, plasma vasopressin...

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Source

Identifiers

PMID: 10644657
DOI: 10.1152/ajprenal.2000.278.1.F75

Genes

ANG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10644657-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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