Article
Microsatellite instability and p53 mutations in hepatocellular carcinoma.
Molecular cell biology research communications : MCBRC - 1 Jan 2000
Karachristos A, Liloglou T, Field J K, Deligiorgi E, Kouskouni E, Spandidos D A
Abstract excerpt
We have studied 27 hepatocellular carcinomas (HCCs) to identify possible relationships between microsatellite instability (MSI), p53 mutations, and HBV infection in hepatocarcinogenesis. MSI was assessed using 19 polymorphic markers and the poly(A) tract BAT-26. All coding regions of p53 were examined for mutations. Tumors were also examined for presence of hepatitis B virus (HBV) DNA sequences; 66.6% of the...
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