Article
Frequent chromosomal instability but no microsatellite instability in hepatocellular carcinomas.
International journal of oncology - 1 Sept 2000
Piao Z, Kim H, Malkhosyan S, Park C
Abstract excerpt
Microsatellite instability (MSI) phenotype, caused by a deficiency of DNA mismatch repair genes, has been detected in a subset of tumors in the gastrointestinal tract. However, it is not clear how MSI is involved in the tumorigenesis of hepatocellular carcinomas (HCC). Results with HCC are controversial, with positive results published with American and European tumors, but negative with Japanese tumors. We...
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