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Article

Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells.

Cellular and molecular life sciences : CMLS - 1 Mar 2009

Viana R J S, Nunes A F, Castro R E, Ramalho R M, Meyerson J, Fossati S, Ghiso J, Rostagno A, Rodrigues C M P

Abstract excerpt

The vasculotropic E22Q mutant of the amyloid-beta (Abeta) peptide is associated with hereditary cerebral hemorrhage with amyloidosis Dutch type. The cellular mechanism(s) of toxicity and nature of the AbetaE22Q toxic assemblies are not completely understood. Comparative assessment of structural parameters and cell death mechanisms elicited in primary human cerebral endothelial cells by AbetaE22Q and wild-type...

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Identifiers

PMID: 19189048
DOI: 10.1007/s00018-009-8746-x
PMCID: PMC2760857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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