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Article

DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos.

Nature cell biology - 1 Feb 2000

Sibon O C, Kelkar A, Lemstra W, Theurkauf W E

Abstract excerpt

During early embryogenesis of Drosophila melanogaster, mutations in the DNA-replication checkpoint lead to chromosome-segregation failures. Here we show that these segregation failures are associated with the assembly of an anastral microtubule spindle, a mitosis-specific loss of centrosome function, and dissociation of several components of the gamma-tubulin ring complex from a core centrosomal structure. The...

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PMID: 10655588
DOI: 10.1038/35000041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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