Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of homodimers in surfactant protein B function in vivo.

The Journal of biological chemistry - 4 Feb 2000

Beck D C, Ikegami M, Na C L, Zaltash S, Johansson J, Whitsett J A, Weaver T E

Abstract excerpt

Surfactant protein B (SP-B) is detected in the airways as a sulfhydryl-dependent dimer (M(r) approximately 16,000). To test the hypothesis that formation of homodimers is critical for SP-B function, the cysteine residue reported to be involved in SP-B dimerization was mutated to serine (Cys(248) --> Ser) and the mutated protein was targeted to the distal respiratory epithelium of transgenic mice. Transgenic lines...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Structure-Activity Relationship
Share to Apoproteins
Share to Dimerization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Mutation

Share to Pulmonary Surfactant-Associated Proteins

Share to Pulmonary Surfactants

Source

Identifiers

PMID: 10652327
DOI: 10.1074/jbc.275.5.3365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of homodimers in surfactant protein B function in vivo.PMID 10652327Read ↗

Ablation of a critical surfactant protein B intramolecular disulfide bond in transgenic mice.Semantic proximity Read ↗

Differential susceptibility of transgenic mice expressing human surfactant protein B genetic variants to Pseudomonas aeruginosa induced pneumonia.Semantic proximity Read ↗

Rescue of SP-B knockout mice with a truncated SP-B proprotein. Function of the C-terminal propeptide.Semantic proximity Read ↗

Surfactant protein B corrects oxygen-induced pulmonary dysfunction in heterozygous surfactant protein B-deficient mice.Semantic proximity Read ↗

N-terminally extended surfactant protein (SP) C isolated from SP-B-deficient children has reduced surface activity and inhibited lipopolysaccharide binding.Semantic proximity Read ↗

Overexpression of surfactant protein-C mature peptide causes neonatal lethality in transgenic mice.Semantic proximity Read ↗

Regulatory Roles of Human Surfactant Protein B Variants on Genetic Susceptibility to Pseudomonas Aeruginosa Pneumonia-Induced Sepsis.Semantic proximity Read ↗

Differences In The Alveolar Macrophage Proteome In Transgenic Mice Expressing Human SP-A1 And SP-A2Semantic proximity Read ↗

Role of N-glycosylation of surfactant protein SP-BN in lipid and SP-B interacting properties. Implications in disease.Semantic proximity Read ↗

Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure.Semantic proximity Read ↗

Surfactant protein B (SP-B) -/- mice are rescued by restoration of SP-B expression in alveolar type II cells but not Clara cells.Semantic proximity Read ↗

Pathophysiology and treatment of surfactant protein-B deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.