Regulatory Roles of Human Surfactant Protein B Variants on Genetic Susceptibility to Pseudomonas Aeruginosa Pneumonia-Induced Sepsis.

doi:10.1097/SHK.0000000000001494

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Regulatory Roles of Human Surfactant Protein B Variants on Genetic Susceptibility to Pseudomonas Aeruginosa Pneumonia-Induced Sepsis.

Shock (Augusta, Ga.) - 1 Oct 2020

Yang Fengyong, Zhang Jing, Yang Yi, Ruan Feng, Chen Xinghua, Guo Junping, Abdel-Razek Osama, Zuo Yi Y, Wang Guirong

Abstract excerpt

Surfactant protein B (SP-B) is essential for life and plays critical roles in host defense and lowering alveolar surface tension. A single-nucleotide polymorphism (SNP rs1130866) of human SP-B (hSP-B) alters the N-linked glycosylation, thus presumably affecting SP-B function. This study has investigated the regulatory roles of hSP-B genetic variants on lung injury in pneumonia-induced sepsis. METHODS: Wild-type...

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PMID: 31851120
DOI: 10.1097/SHK.0000000000001494
PMCID: PMC10336628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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