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Article

Ablation of a critical surfactant protein B intramolecular disulfide bond in transgenic mice.

The Journal of biological chemistry - 4 Feb 2000

Beck D C, Na C L, Whitsett J A, Weaver T E

Abstract excerpt

The 79-amino acid, mature SP-B peptide contains three intramolecular disulfide bonds shared by all saposin-like proteins. This study tested the hypothesis that the disulfide bond formed between cysteine residues 35 and 46 (residues 235 and 246 of the SP-B proprotein) is essential for proper function of SP-B. To test the role of this bridge in SP-B function in vivo, a construct was generated in which cysteine...

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Identifiers

PMID: 10652328
DOI: 10.1074/jbc.275.5.3371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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