Article
p53 and PCNA expression in benign, atypical and malignant meningiomas.
JPMA. The Journal of the Pakistan Medical Association - 1 Oct 1999
Ahmed R, Soomro I N, Aziz S A, Hasan S H
Abstract excerpt
OBJECTIVE: Alterations: p53 genes are turning out to be the most common genetic alterations in human cancers. Due to long half-life of mutated p53, its detection is possible by immunohistochemistry. Proliferating cell nuclear antigen (PCNA) is expressed by dividing cells, hence has been shown to correlate with prognosis. We have used monoclonal antibodies protein DO-7 (p53) and PC10 (PCNA) to see whether their...
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