Article
Evaluation of relationship between chromosome 22 and p53 gene alterations and the subtype of meningiomas by the interphase-FISH technique.
Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 2002
Yakut Tahsin, Bekar Ahmet, Doygun Muammer, Acar Hasan, Egeli Unal, Ogul Erhan
Abstract excerpt
In this study, we investigated the relationship between genetic alterations such as chromosome 22 aneuploidy and p53 gene deletion, and the pathological types of meningioma of typical and aggressive forms. Thirty-four meningiomas (23 typical and 11 aggressive) were examined by application of fluorescence in situ hybridization (FISH) with chromosome 22 specific alpha satellite probe and a combination of p53 locus...
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