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Article

Distinct roles for the helicases of TFIIH in transcript initiation and promoter escape.

The Journal of biological chemistry - 28 Jan 2000

Bradsher J, Coin F, Egly J M

Abstract excerpt

To provide an explanation of some clinical features observed within rare xeroderma pigmentosum (XP) patients and to further define the role of XPB, XPD, and cdk7, the three enzymatic subunits of TFIIH, in the transcription reaction, we have examined two defined enzymatic steps: phosphodiester bond formation and promoter escape. We provide evidence that the XPB helicase plays a dominant role in initiation, whereas...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10644710
DOI: 10.1074/jbc.275.4.2532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Distinct roles for the helicases of TFIIH in transcript initiation and promoter escape.PMID 10644710Read ↗

A role for the TFIIH XPB DNA helicase in promoter escape by RNA polymerase II.Semantic proximity Read ↗

TFIIH: from transcription to clinicSemantic proximity Read ↗

A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor.Semantic proximity Read ↗

Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum.Semantic proximity Read ↗

TFIIH is an elongation factor of RNA polymerase I.Semantic proximity Read ↗

Mutations in XPB and XPD helicases found in xeroderma pigmentosum patients impair the transcription function of TFIIH.Semantic proximity Read ↗

Transcription without XPB Establishes a Unified Helicase-Independent Mechanism of Promoter Opening in Eukaryotic Gene Expression.Semantic proximity Read ↗

ARCH domain of XPD, an anchoring platform for CAK that conditions TFIIH DNA repair and transcription activities.Semantic proximity Read ↗

The role of XPB/Ssl2 dsDNA translocation processivity in transcription-start-site scanningSemantic proximity Read ↗

Stimulation of the XPB ATP-dependent helicase by the beta subunit of TFIIE.Semantic proximity Read ↗

A 3′→ 5′ XPB Helicase Defect in Repair/Transcription Factor TFIIH of Xeroderma Pigmentosum Group B Affects Both DNA Repair and TranscriptionSemantic proximity Read ↗

Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization.Semantic proximity Read ↗

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