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Article

A role for the TFIIH XPB DNA helicase in promoter escape by RNA polymerase II.

The Journal of biological chemistry - 6 Aug 1999

Moreland R J, Tirode F, Yan Q, Conaway J W, Egly J M, Conaway R C

Abstract excerpt

TFIIH is an RNA polymerase II transcription factor that performs ATP-dependent functions in both transcription initiation, where it catalyzes formation of the open complex, and in promoter escape, where it suppresses arrest of the early elongation complex at promoter-proximal sites. TFIIH possesses three known ATP-dependent activities: a 3' --> 5' DNA helicase catalyzed by its XPB subunit, a 5' --> 3' DNA...

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Share to Adenosine Triphosphate
Share to Cyclin-Dependent Kinases
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Serine-Threonine Kinases

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Share to Transcription Factors, TFII

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Source

Identifiers

PMID: 10428772
DOI: 10.1074/jbc.274.32.22127

Genes

CDK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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A role for the TFIIH XPB DNA helicase in promoter escape by RNA polymerase II.PMID 10428772Read ↗

Distinct roles for the helicases of TFIIH in transcript initiation and promoter escape.Semantic proximity Read ↗

Transcription without XPB Establishes a Unified Helicase-Independent Mechanism of Promoter Opening in Eukaryotic Gene Expression.Semantic proximity Read ↗

Stimulation of the XPB ATP-dependent helicase by the beta subunit of TFIIE.Semantic proximity Read ↗

Regulation of promoter-proximal transcription elongation: enhanced DNA scrunching drives λQ antiterminator-dependent escape from a σ70-dependent pause.Semantic proximity Read ↗

TFIIH is an elongation factor of RNA polymerase I.Semantic proximity Read ↗

The role of XPB/Ssl2 dsDNA translocation processivity in transcription-start-site scanningSemantic proximity Read ↗

Interplay between σ region 3.2 and secondary channel factors during promoter escape by bacterial RNA polymerase.Semantic proximity Read ↗

Rad25p, a DNA helicase subunit of yeast transcription factor TFIIH, is required for promoter escape in vivo.Semantic proximity Read ↗

Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization.Semantic proximity Read ↗

Inhibition of TFIIH translocase reveals a novel lncRNA regulatory network at the BRCA1 locusSemantic proximity Read ↗

Mechanism of start site selection by RNA polymerase II: interplay between TFIIB and Ssl2/XPB helicase subunit of TFIIH.Semantic proximity Read ↗

Release of human TFIIB from actively transcribing complexes is triggered upon synthesis of 7 nt and 9 nt RNAsSemantic proximity Read ↗

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