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Article

A 3′→ 5′ XPB Helicase Defect in Repair/Transcription Factor TFIIH of Xeroderma Pigmentosum Group B Affects Both DNA Repair and Transcription

1 Jul 1996

Abstract excerpt

XPB is a subunit of the basal transcription factor TFIIH, which is also involved in nucleotide excision repair (NER) and potentially in cell cycle regulation. A frameshift mutation in the 3'-end of the XPB gene is responsible for a concurrence of two disorders: xeroderma pigmentosum (XP) and Cockayne's syndrome (CS). We have isolated TFIIH from cells derived from a patient (XP11BE) who carries this frameshift...

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Identifiers

PMID: 8663148
DOI: 10.1074/jbc.271.27.15898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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A 3′→ 5′ XPB Helicase Defect in Repair/Transcription Factor TFIIH of Xeroderma Pigmentosum Group B Affects Both DNA Repair and TranscriptionPMID 8663148Read ↗

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Xeroderma pigmentosum and related disorders: defects in DNA repair and transcription.Semantic proximity Read ↗

The Role of TFIIH Complex in Nucleotide Excision RepairSemantic proximity Read ↗

The relative expression of mutated XPB genes results in xeroderma pigmentosum/Cockayne's syndrome or trichothiodystrophy cellular phenotypes.Semantic proximity Read ↗

The role of Transcription Factor IIH complex in nucleotide excision repairSemantic proximity Read ↗

TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.Semantic proximity Read ↗

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