Prevention by blockade of angiotensin subtype1-receptors of the development of genetic hypertension but not its heritability.

doi:10.1111/j.1476-5381.1995.tb14968.x

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Article

Prevention by blockade of angiotensin subtype1-receptors of the development of genetic hypertension but not its heritability.

British journal of pharmacology - 1 Jun 1995

Madeddu P, Anania V, Varoni M V, Parpaglia P P, Demontis M P, Fattaccio M C, Palomba D, Pollock D, Glorioso N

Abstract excerpt

1. We determined whether early inhibition of angiotensin II subtype1 (AT1) receptors by the newly synthesized nonpeptidic antagonist, A-81988, can attenuate the development of hypertension in spontaneously hypertensive rats (SHR) and if the altered blood pressure phenotype can be passed on to the...

Topics

Administration, Oral
Angiotensin II
Angiotensin Receptor Antagonists
Animals
Antihypertensive Agents
Biomarkers
Blood Pressure
Body Weight
Disease Models, Animal
Diuresis
Female
Genetic Diseases, Inborn
Heart
Hypertension

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Injections, Intravenous

Injections, Intraventricular

Male

Nicotinic Acids

Source

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Identifiers

PMID: 7582472
DOI: 10.1111/j.1476-5381.1995.tb14968.x
PMCID: PMC1908501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7582472-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.