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Article

Prevention by blockade of angiotensin subtype1-receptors of the development of genetic hypertension but not its heritability.

British journal of pharmacology - 1 Jun 1995

Madeddu P, Anania V, Varoni M V, Parpaglia P P, Demontis M P, Fattaccio M C, Palomba D, Pollock D, Glorioso N

Abstract excerpt

1. We determined whether early inhibition of angiotensin II subtype1 (AT1) receptors by the newly synthesized nonpeptidic antagonist, A-81988, can attenuate the development of hypertension in spontaneously hypertensive rats (SHR) and if the altered blood pressure phenotype can be passed on to the subsequent generation, not exposed to the antagonist. 2. Pairs of SHR were mated while drinking tap water or A-81988...

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Identifiers

PMID: 7582472
DOI: 10.1111/j.1476-5381.1995.tb14968.x
PMCID: PMC1908501

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Source receipt: pubmed, retrieved 7 Sept 2026.

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