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Article

Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A streptococcus M1T1 clone.

The Journal of infectious diseases - 1 Jul 2010

Hollands Andrew, Pence Morgan A, Timmer Anjuli M, Osvath Sarah R, Turnbull Lynne, Whitchurch Cynthia B, Walker Mark J, Nizet Victor

Abstract excerpt

BACKGROUND: The recent resurgence of invasive group A streptococcal disease has been paralleled by the emergence of the M1T1 clone. Recently, invasive disease initiation has been linked to mutations in the covR/S 2-component regulator. We investigated whether a fitness cost is associated with the covS mutation that counterbalances hypervirulence. METHODS: Wild-type M1T1 group A Streptococcus and an isogenic...

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Identifiers

PMID: 20507231
DOI: 10.1086/653124
PMCID: PMC2880657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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