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Article

Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil.

Molecular pharmacology - 1 Dec 2000

Reimann F, Gribble F M, Ashcroft F M

Abstract excerpt

ATP-sensitive K-channels (K(ATP) channels) are the target for K(ATP)-channel openers (KCOs), such as pinacidil and P1075. These channels are formed from pore-forming Kir6.2 and regulatory sulfonylurea receptors (SUR2A in heart and skeletal muscle; SUR2B in smooth muscle). The two isoforms of SUR2 differ only in their final 42 amino acids, a region that includes neither the Walker A and B nucleotide binding motifs...

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Identifiers

PMID: 11093769
DOI: 10.1124/mol.58.6.1318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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