Article
Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.
Cancer research - 1 May 2008
Meoli Elise, Bossis Ioannis, Cazabat Laure, Mavrakis Manos, Horvath Anelia, Stergiopoulos Sotiris, Shiferaw Miriam L, Fumey Glawdys, Perlemoine Karine, Muchow Michael, Robinson-White Audrey, Weinberg Frank, Nesterova Maria, Patronas Yianna, Groussin Lionel, Bertherat Jérôme, Stratakis Constantine A
Abstract excerpt
Most PRKAR1A tumorigenic mutations lead to nonsense mRNA that is decayed; tumor formation has been associated with an increase in type II protein kinase A (PKA) subunits. The IVS6+1G>T PRKAR1A mutation leads to a protein lacking exon 6 sequences [R1 alpha Delta 184-236 (R1 alpha Delta 6)]. We compared in vitro R1 alpha Delta 6 with wild-type (wt) R1 alpha. We assessed PKA activity and subunit expression,...
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