Article
Divergent role for TNF-alpha in IFN-gamma-induced killing of Toxoplasma gondii and Salmonella typhimurium contributes to selective susceptibility of patients with partial IFN-gamma receptor 1 deficiency.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2002
Janssen Riny, Van Wengen Annelies, Verhard Els, De Boer Tjitske, Zomerdijk Timo, Ottenhoff Tom H M, Van Dissel Jaap T
Abstract excerpt
Patients with defects in IFN-gamma- or IL-12-mediated immunity are susceptible to infections with Salmonella and non-tuberculous mycobacteria, but rarely suffer from infections with other intracellular pathogens such as Toxoplasma gondii. Here we describe macrophage and T cell function in eight individuals with partial IFN-gamma receptor 1 (IFN-gammaR1) deficiency due to a mutation that results in elevated cell...
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