Article
In vivo selection of functional ribosomes with variations in the rRNA-binding site of Escherichia coli ribosomal protein S8: evolutionary implications.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2000
Moine H, Squires C L, Ehresmann B, Ehresmann C
Abstract excerpt
The highly conserved nature of rRNA sequences throughout evolution allows these molecules to be used to build philogenic trees of different species. It is unknown whether the stability of specific interactions and structural features of rRNA reflects an optimal adaptation to a functional task or an evolutionary trap. In the work reported here, we have applied an in vivo selection strategy to demonstrate that...
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