Article
Isolation of antibiotic resistance mutations in the rRNA by using an in vitro selection system.
Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2004
Cochella Luisa, Green Rachel
Abstract excerpt
Genetic, biochemical, and structural data support an essential role for the ribosomal RNA in all steps of the translation process. Although in vivo genetic selection techniques have been used to identify mutations in the rRNAs that result in various miscoding phenotypes and resistance to known ribosome-targeted antibiotics, these are limited because the resulting mutant ribosomes must be only marginally disabled...
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