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Article

Optimization of a ribosomal structural domain by natural selection.

Biochemistry - 30 May 2006

Maeder Corina, Conn Graeme L, Draper David E

Abstract excerpt

A conserved, independently folding domain in the large ribosomal subunit consists of 58 nt of rRNA and a single protein, L11. The tertiary structure of an rRNA fragment carrying the Escherichia coli sequence is marginally stable in vitro but can be substantially stabilized by mutations found in other organisms. To distinguish between possible reasons why natural selection has not evolved a more stable rRNA...

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Identifiers

PMID: 16716074
DOI: 10.1021/bi052544p
PMCID: PMC2698295

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Source receipt: pubmed, retrieved 7 Sept 2026.

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