Article
Investigation of mutant frequency at the HPRT locus and changes in microsatellite sequences in healthy young adults.
Mutation research - 17 Dec 1999
Davies M J, Turner J G, Vives-Bauza C, Rumsby P C
Abstract excerpt
In an attempt to understand the inter-individual variation that occurs in in vivo mutant frequency at the HPRT locus, we have examined the effect of polymorphisms in genes for metabolic enzymes on the mutation rate. In the same population of human volunteers, the background variant frequency in a number of microsatellite sequences was studied to determine individual variation in the capacity to repair mismatches...
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