Article
Association of bone mineral density with polymorphism of the human matrix Gla protein locus in elderly women.
Journal of bone and mineral metabolism - 1 Jan 2000
Tsukamoto K, Orimo H, Hosoi T, Miyao M, Yoshida H, Watanabe S, Suzuki T, Emi M
Abstract excerpt
The contribution of genetic factors has been implicated in the determination of bone mass in twin and family studies. Some of the genes involved would regulate bone metabolism, bone formation, and resorption, all processes that determine bone mass. One candidate gene matrix Gla protein gene (MGP), has been implicated in the pathogenesis of bone loss through a repression of bone formation. To analyze the genetic...
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