Synergism and antagonism between N-methyl-N'-nitro-N-nitroso-guanidine and 9-aminoacridine in mutation induction in Escherichia coli K12.

doi:10.1093/mutage/8.4.295

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Article

Synergism and antagonism between N-methyl-N'-nitro-N-nitroso-guanidine and 9-aminoacridine in mutation induction in Escherichia coli K12.

Mutagenesis - 1 Jul 1993

Pons F W, Adler-Bollinger A, Müller P

Abstract excerpt

When bacteria were treated simultaneously with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and low concentrations of 9-aminoacridine (9AA), the yield of frameshift mutations was much greater than that expected on the basis of independent action of both mutagens. In combination with a high concent...

Topics

Aminacrine
DNA, Bacterial
Drug Interactions
Escherichia coli
Frameshift Mutation
Methylation
Methylnitronitrosoguanidine
Mutation

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