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Article

Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper.

The EMBO journal - 1 Mar 2001

Thress K, Song J, Morimoto R I, Kornbluth S

Abstract excerpt

Protein folding mediated by the Hsp70 family of molecular chaperones requires both ATP and the co-chaperone Hdj-1. BAG-1 was recently identified as a bcl-2-interacting, anti-apoptotic protein that binds to the ATPase domain of Hsp70 and prevents the release of the substrate. While this suggested that cells had the potential to modulate Hsp70-mediated protein folding, physiological regulators of BAG-1 have yet to...

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Identifiers

PMID: 11230127
DOI: 10.1093/emboj/20.5.1033
PMCID: PMC145500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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