Article
Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease.
Journal of gastroenterology and hepatology - 1 Jul 2009
Takatsu Noritaka, Matsui Toshiyuki, Murakami Yuji, Ishihara Hiroshi, Hisabe Takashi, Nagahama Takashi, Maki Shinichirou, Beppu Takahiro, Takaki Yasuhiro, Hirai Fumihito, Yao Kenshi
Abstract excerpt
BACKGROUND AND AIMS: Azathioprine (AZA) is associated with a high frequency of adverse reactions. We examined polymorphism of the thiopurine S-methyltransferase (TPMT) gene to determine whether the TPMT genotype would be a predictive marker for the development of adverse reactions to AZA. METHODS: The frequency of TPMT mutations was investigated in 147 Japanese inflammatory bowel disease (IBD) patients...
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