Article
Decreased serotonin transporter binding in unaffected relatives of manic depressive patients.
Biological psychiatry - 15 Dec 1999
Leboyer M, Quintin P, Manivet P, Varoquaux O, Allilaire J F, Launay J M
Abstract excerpt
BACKGROUND: There are numerous reports of decreased binding to platelet serotonin transporter (5-HTT) in depression, suggesting that it might be considered a trait marker of depression. To further investigate whether reduced 5-HTT function could be an endophenotype in manic depressive illness, we looked for abnormalities of platelet 5-HTT among subjects who are potential carriers of genetic vulnerability to manic...
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