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Article

Differential fates of invertase mutants in the yeast endoplasmic reticulum.

Yeast (Chichester, England) - 15 Jan 2000

McCracken A A, Werner E D, Powell M J, Kruse K B, Brodsky J L

Abstract excerpt

A number of proteins have been identified as substrates for endoplasmic reticulum (ER)-associated protein degradation (ERAD) and we describe here a new model substrate with which to study this process. Two secretion-defective forms of yeast invertase that accumulated in the ER to greatly different levels were examined: Suc2-538p levels were low, while Suc2-533p was present in high amounts. Because Suc2-533p and...

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PMID: 10620774
DOI: 10.1002/(SICI)1097-0061(20000115)16:1<49::AID-YEA506>3.0.CO;2-I

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