Article
Expression and degradation of the cystic fibrosis transmembrane conductance regulator in Saccharomyces cerevisiae.
Archives of biochemistry and biophysics - 15 Jun 2001
Kiser G L, Gentzsch M, Kloser A K, Balzi E, Wolf D H, Goffeau A, Riordan J R
Abstract excerpt
Many cystic fibrosis disease-associated mutations cause a defect in the biosynthetic processing and trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Yeast mutants, defective at various steps of the secretory pathway, have been used to dissect the mechanisms of biosynthetic processing and intracellular transport of several proteins. To exploit these yeast mutants, we have...
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