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Article

Two oligosaccharyl transferase complexes exist in yeast and associate with two different translocons.

Glycobiology - 1 Dec 2005

Yan Aixin, Lennarz William J

Abstract excerpt

Oligosaccharyl transferase (OT) scans and selectively glycosylates -Asn-X-Thr/Ser-motifs in nascent polypeptide chains in the endoplasmic reticulum (ER). Several groups have reported different results for the composition of this enzyme complex. In this study, using a membrane protein two-hybrid approach, the split-ubiquitin system, we show that except for Ost3p and Ost6p, all of the other subunits of OT exist as...

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Identifiers

PMID: 16096345
DOI: 10.1093/glycob/cwj026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two oligosaccharyl transferase complexes exist in yeast and associate with two different translocons.PMID 16096345Read ↗

Subunits of the translocon interact with components of the oligosaccharyl transferase complex.Semantic proximity Read ↗

The oligosaccharyltransferase complex from Saccharomyces cerevisiae. Isolation of the OST6 gene, its synthetic interaction with OST3, and analysis of the native complex.Semantic proximity Read ↗

DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon.Semantic proximity Read ↗

Polypeptide binding specificities of Saccharomyces cerevisiae oligosaccharyltransferase accessory proteins Ost3p and Ost6p.Semantic proximity Read ↗

Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein.Semantic proximity Read ↗

A specific segment of the transmembrane domain of Wbp1p is essential for its incorporation into the oligosaccharyl transferase complex.Semantic proximity Read ↗

The Saccharomyces cerevisiae oligosaccharyltransferase: a large hetero-oligomeric complex in the endoplasmic reticulum.Semantic proximity Read ↗

Distinct domains within yeast Sec61p involved in post-translational translocation and protein dislocation.Semantic proximity Read ↗

Alg13p, the catalytic subunit of the endoplasmic reticulum UDP-GlcNAc glycosyltransferase, is a target for proteasomal degradation.Semantic proximity Read ↗

Studies on the role of the hydrophobic domain of Ost4p in interactions with other subunits of yeast oligosaccharyl transferase.Semantic proximity Read ↗

The STT3 protein is a component of the yeast oligosaccharyltransferase complex.Semantic proximity Read ↗

Lipid biosynthesis perturbation impairs endoplasmic reticulum-associated degradation.Semantic proximity Read ↗

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