Article
Association of monoamine oxidase B alleles with age at onset in amyotrophic lateral sclerosis.
Neuromuscular disorders : NMD - 1 Dec 1999
Orrù S, Mascia V, Casula M, Giuressi E, Loizedda A, Carcassi C, Giagheddu M, Contu L
Abstract excerpt
An active role of monoamine oxidase B (MAO-B) in the pathogenesis of neurodegenerative disorders such as Parkinson's disease has been proposed as the enzyme is known to be a generator of free radicals which seem to be responsible for neuron oxidative damage. We evaluated the influence of MAO-B in the pathogenesis of the sporadic forms of Amyotrophic lateral sclerosis (ALS) by studying the MAO-B allele...
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