Association of a monoamine oxidase B allele with Parkinson's disease.

doi:10.1002/ana.410330406

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Article

Association of a monoamine oxidase B allele with Parkinson's disease.

Annals of neurology - 1 Apr 1993

Kurth J H, Kurth M C, Poduslo S E, Schwankhaus J D

Abstract excerpt

Monoamine oxidase B (MAO-B) is implicated in the cause of Parkinson's disease (PD) because of its role in metabolizing the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, and forming H2O2 during dopamine metabolism. Altered MAO-B activity has been observed in PD platelets. Polymerase cha...

Topics

Aged
Alleles
Base Sequence
Female
Humans
Male
Molecular Probes
Molecular Sequence Data
Monoamine Oxidase
Parkinson Disease
Polymerase Chain Reaction
Polymorphism, Genetic

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