Article
Frequency of a tau genotype in amyotrophic lateral sclerosis.
Journal of the neurological sciences - 15 Sept 2005
Münch Christoph, Prechter Florian, Xu Renshi, Linke Peter, Prudlo Johannes, Kuzma Magdalena, Kwiecinski Hubert, Ludolph Albert C, Meyer Thomas
Abstract excerpt
We investigated the susceptibility of the dinucleotide polymorphism A0 in the tau gene to amyotrophic lateral sclerosis (ALS). In 416 unrelated patients with ALS and 242 control subjects the A0/A0 genotype was not associated with the pooled sample of ALS cases. Subgroup analysis revealed that in sporadic ALS the A0 polymorphism was significantly overrepresented. There was no association of the A0/A0 genotype with...
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