Article
Association of a polymorphism in intron 13 of the monoamine oxidase B gene with Parkinson disease.
American journal of medical genetics - 18 Apr 1997
Costa P, Checkoway H, Levy D, Smith-Weller T, Franklin G M, Swanson P D, Costa L G
Abstract excerpt
Monoamine oxidase B (MAO-B) is an enzyme that has relevance for Parkinson disease (PD) because of its roles in catabolizing dopamine and potentially activating exogenous neurotoxicants. A polymorphism of the gene encoding MAO-B has been identified as a single base change (A or G) in intron 13 of the X chromosome. The A allele was previously associated with an approximately twofold risk of PD. The present study...
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