Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endogenous mutations in human uncoupling protein 3 alter its functional properties.

FEBS letters - 31 Dec 1999

Brown A M, Dolan J W, Willi S M, Garvey W T, Argyropoulos G

Abstract excerpt

Human uncoupling protein (UCP3) is a mitochondrial transmembrane carrier that uncouples oxidative phosphorylation and is a candidate gene for obesity. Expression of native human UCP3 mutations in yeast showed complete loss (R70W), significant reduction (R143X), or no effect (V102I and IVS6+1G > A) on the uncoupling activity of UCP3. It is concluded that certain mutations in UCP3 alter its functional impact on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to DNA, Complementary
Share to Ion Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria

Share to Mitochondrial Proteins

Share to Mutation

Share to Saccharomyces cerevisiae

Share to Uncoupling Protein 3

Source

Identifiers

PMID: 10618503
DOI: 10.1016/s0014-5793(99)01708-1

Genes

UCP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endogenous mutations in human uncoupling protein 3 alter its functional properties.PMID 10618503Read ↗

The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis.Semantic proximity Read ↗

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes.Semantic proximity Read ↗

Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes.Semantic proximity Read ↗

Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsideredSemantic proximity Read ↗

The energetic implications of uncoupling protein-3 in skeletal muscle.Semantic proximity Read ↗

Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes.Semantic proximity Read ↗

Uncoupling proteins: the issues from a biochemist point of view.Semantic proximity Read ↗

Association between uncoupling protein 3 gene and obesity-related phenotypes in the Québec Family Study.Semantic proximity Read ↗

Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene.Semantic proximity Read ↗

Four novel UCP3 gene variants associated with childhood obesity: effect on fatty acid oxidation and on prevention of triglyceride storage.Semantic proximity Read ↗

Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity.Semantic proximity Read ↗

Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.