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Article

Plasminogen activator inhibitor-1 4G/5G polymorphism and risk of stroke: replicated findings in two nested case-control studies based on independent cohorts.

Stroke - 1 Aug 2005

Wiklund Per-Gunnar, Nilsson Lennart, Ardnor Sofie Nilsson, Eriksson Per, Johansson Lars, Stegmayr Birgitta, Hamsten Anders, Holmberg Dan, Asplund Kjell

Abstract excerpt

BACKGROUND AND PURPOSE: Impaired fibrinolytic function secondary to elevated plasminogen activator inhibitor-1 (PAI-1) levels has been implicated in ischemic stroke. PAI-1 levels are determined by genetic factors and environmental factors, triglyceride levels in particular. The aim of this study was to investigate the common functional 4/5 guanosine (4G/5G) polymorphism in the promoter region of the PAI-1 gene...

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Identifiers

PMID: 16020771
DOI: 10.1161/01.STR.0000174485.10277.24

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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