Article
Analysis of multiple data sets reveals no association between the insulin gene variable number tandem repeat element and polycystic ovary syndrome or related traits.
The Journal of clinical endocrinology and metabolism - 1 May 2005
Powell Brenda L, Haddad Lema, Bennett Amanda, Gharani Neda, Sovio Ulla, Groves Christopher J, Rush Karen, Goh Micaela J, Conway Gerard S, Ruokonen Aimo, Martikainen Hannu, Pouta Anneli, Taponen Saara, Hartikainen Anna-Liisa, Halford Stephanie, Zeggini Eleftheria, Järvelin Marjo-Riitta, Franks Steve, McCarthy Mark I
Abstract excerpt
CONTEXT: Variation at the insulin gene VNTR (variable number tandem repeat) minisatellite has been reported to be associated with polycystic ovary syndrome (PCOS), but findings have been inconsistent and all studies have featured small sample sizes. OBJECTIVE: To gain a robust understanding of the role of the INS-VNTR in PCOS susceptibility. DESIGN: Case-control, family-based association and quantitative trait...
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