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Article

Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system

1 Sept 1999

Abstract excerpt

OBJECTIVE: Methylation of the promoter region of the estrogen receptor gene alpha (ER alpha) occurs as a function of age in human colon, and results in inactivation of gene transcription. In this study, we sought to determine whether such age-related methylation occurs in the cardiovascular system, and whether it is associated with atherosclerotic disease. METHODS: We used Southern blot analysis to determine the...

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Share to Epigenetics and DNA Methylation
Share to Estrogen and related hormone effects
Share to Menopause: Health Impacts and Treatments

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PMID: 10615426
DOI: 10.1016/s0008-6363(99)00153-4

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