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Article

Estrogen Modulates AT 1 Receptor Gene Expression In Vitro and In Vivo

9 Jun 1998

Abstract excerpt

BACKGROUND: The AT1 receptor has been implicated in the pathogenesis of hypertension and atherosclerosis. Estrogen deficiency is also associated with cardiovascular diseases. Therefore, we examined the AT1 receptor gene expression in ovariectomized rats with and without estrogen replacement therapy and the influence of estrogen on AT1 receptor expression in cultured vascular smooth muscle cells. METHODS AND...

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PMID: 9631868
DOI: 10.1161/01.cir.97.22.2197

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